William married Mary Kirkham in 1790 in Wake County, North Carolina, USA. Mary was born in 1772 in Wake County, North Carolina, USA; died in 1820 in Wake County, North Carolina, USA. [Group Sheet] [Family Chart]

1. James Kirkum Weatherspoon was born on 5 May 1801 in North Carolina, USA; died on 17 Mar 1844; was buried in Palestine Methodist Church Cemetery, Fulton County, Kentucky, USA.
2. Willis Weatherspoon was born in 1791 in Wake County, North Carolina, USA; died in 1850 in Hickman County, Tennessee, USA; was buried in Old Weatherspoon Cemetery, Hickman County, Tennessee, USA.
3. Bethany Weatherspoon was born about 1813 in North Carolina, USA; died in 1885; was buried in Pleasant Hill Cemetery, Water Valley, Graves, Kentucky, USA.
4. Rebecca Weatherspoon was born about 1805 in North Carolina, USA; died in 1870 in Nacogdoches, Nacogdoches, Texas, USA.
5. Ezekial Weatherspoon was born about 1804 in North Carolina, USA; died in 1825 in North Carolina, USA.
6. Frances 'Fanny' Weatherspoon was born about 1806 in Wake County, North Carolina, USA; died in 1870 in Wake County, North Carolina, USA.
7. Delilah Weatherspoon was born about 1799 in North Carolina, USA; died in 1871 in Wake County, North Carolina, USA.
8. Nancy Weatherspoon was born about 1793 in Wake County, North Carolina, USA; died about 1860.
9. Celia Weatherspoon was born about 1795 in Wake County, North Carolina, USA; died after 1833; was buried in Stone Shipp Cemetery, Clegg, Wake, North Carolina, USA.

William married Delha Bellamy. [Group Sheet] [Family Chart]